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OCR: agnostic GnRH has been extensively tested as a d es of agent in differentiating between the caus e pituitary hypogonadism. In patients with comple destruction, GnRH does not stimulate atients gonadotrophic hormone release, but in on with lesser degrees of pituitary dysfuncti ay induce aassociated with hypogonadism, GnRH m nal range, gonadotrophin response within the non i can lead Long-standing hypothalamic dysfunction s. For theseto poor or absent pituitary responsivene of GnRH reasons therefore, a single bolus injection is a poor differential diagnostic agent. See later: . Intermittent GnRH Injections . Constant-Rate GnRH Administration